Is fibromyalgia a central sensitization disorder?
Fibromyalgia syndrome (FM), the most common central sensitivity syndrome (CSS) affecting over 5% of the population, is a disorder of chronic widespread pain accompanied by numerous other symptoms that causes significant functional impairment.
How do you treat central sensitization?
Often used drugs to treat central sensitization include:
- acetaminophen (paracetamol) – primarily acts centrally reinforcing descending inhibitory pathways.
- serotonin- and norepinephrine-reuptake inhibitors – activate noradrenergic descending pathways together with serotonergic pathways.
What are the symptoms of central sensitization?
Symptoms of central sensitization disorders include:
- Widespread pain.
- Abdominal pain.
- Fatigue, poor sleep.
- Headaches.
- Anxiety and depression.
- Poor memory or concentration.
Is central sensitization a neurological disorder?
Central sensitization is a condition of the nervous system associated with the development and maintenance of chronic pain. The confusing part of this condition is that pain itself can change how brain works, resulting in more pain with less provoking stimuli.
Can you reverse central sensitization?
On a cellular/molecular level, central sensitization may be reversed through degradative glutamate receptor pathways. This, however, rarely happens. Instead, cortical brain regions may serve in a top-down regulatory capacity for the maintenance or alleviation of pain.
How do you reverse central sensitization?
Is central sensitization reversible?
Given that degradative pathways exist, the process of central sensitization can be reversed. Activity by astroglial cells, however, may mitigate the effects of receptor degradation by upregulating and facilitating the process of central sensitization.
What is fibromyalgia and what causes it?
The cause of fibromyalgia is unknown. Some researchers believe fibromyalgia originates with a problem in the nervous system, changing the way the brain and nerves process pain signals and increasing sensitivity to pain, cold, and other stimuli. Others believe that fibromyalgia begins with a disorder of the endocrine system,…
What is central sensitization disorder?
Central Sensitization Disorders. Central sensitization occurs when a person becomes more sensitive to pain. The central nervous system is made up of the brain and the spinal cord. Abnormalities in the way the central nervous system processes pain may be responsible for the symptoms experienced in chronic pain disorders.
What is central pain syndrome?
Central pain syndrome. Central pain syndrome is a neurological condition consisting of constant, moderate to severe pain due to damage to the central nervous system (CNS) which causes a sensitization of the pain system.
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