Is Phenylbutazone an acid or base?
Phenylbutazone is a non-steroidal anti-inflammatory drug (NSAID) that exerts its anti-inflammatory action through inhibition of the enzyme cyclo-oxygenase and inhibition of the production of inflammatory medi- ators such as prostaglandins. Phenylbutazone, despite containing nitrogen, is a weak acid with a pKa of 4.4.
Is indomethacin acidic or basic?
Indomethacin has a pKa of 4.5 and is stable in neutral or slightly acidic media and decomposes in strong alkali. The suspension has a pH of 4.0-5.0.
Are barbiturates acidic?
6.2. Barbiturates are 5,5-disubstituted barbituric acid derivatives.
What is pKa of a drug?
The pKa of a drug is the hydrogen ion concentration (pH) at which 50% of the drug exists in its ionized hydrophilic form (i.e., in equilibrium with its un-ionized lipophilic form). At physiologic pH, the lower the pKa the greater the lipophilicity.
What is the pKa of paracetamol?
PARACETAMOL (acetaminophen, N-acetyl-p-amino- phenol, 4-hydroxyacetanilide) is a moderately water- and lipid-soluble weak organic acid. It has a pKa value of 9.5 and is therefore largely unionized over the physiological range ofpH.
What is indomethacin soluble in?
Indomethacin is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of indomethacin in these solvents is approximately 6.73, 17.8, and 20.2 mg/ml, respectively.
What is the chemical formula of indomethacin?
C19H16ClNO4
Indomethacin/Formula
Are barbiturates lipid soluble?
Lipid solubility of the barbiturates is the dominant factor in their distribution within the body. The more lipid soluble the barbiturate, the more rapidly it penetrates all tissues of the body.
What category does barbiturates fall under?
Barbiturates are a group of drugs in the class of drugs known as sedative-hypnotics, which generally describes their sleep-inducing and anxiety-decreasing effects. Barbiturates can be extremely dangerous because the correct dose is difficult to predict.
What is hydroxyzine HCl prescribed for?
Hydroxyzine is used in adults and children to relieve itching caused by allergic skin reactions. It is also used alone or with other medications in adults and children to relieve anxiety and tension.
What is propranolol also called?
Propranolol is available under the following different brand names: Inderal, Inderal LA, InnoPran XL, and Hemangeol.
When was hexobarbital used as an anesthetic?
Hexobarbital is a barbiturate derivative having hypnotic and sedative effects. It was subsequently used in the 1940s and 1950s as an anesthetic for surgery. Furthermore, the agent also demonstrates a fairly quick onset of action that also possesses a short duration of action.
Where does hexobarbital bind in the thalamus?
8.5Mechanism of Action. Hexobarbital binds at a distinct binding site associated with a Cl- ionopore at the GABA-A receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
What is the chemical code for hydrochloric acid?
EPA Pesticide Chemical Code 045901 Hydrochloric acid, for analysis, 25% solution in water Hydrochloric acid, pure, fuming, 37% solution in water
What is the pKa value of phenazine?
pKa Values INDEX Inorganic 2 Phenazine 24 Phosphates 3 Pyridine 25 Carboxylic acids 4, 8 Pyrazine 26 HCO3 10.33* HSe– 11.00* 77 H2CrO4 -0.98 30 H 2S 7.00* 77