What causes 13q deletion?

What causes 13q deletion?

Mechanism. This disorder is caused by the deletion of the long arm of chromosome 13, which can either be deleted linearly or as a ring chromosome. It is typically not hereditary— the loss of a portion of the chromosome typically occurs during gametogenesis, making it a de novo mutation.

How does chromosome deletion happen?

Chromosomal deletions occur spontaneously at a low frequency, or are induced by treatment of germ cells (most efficiently, mature or maturing oocytes in the female, and postmeiotic spermatogenic cells in the male) with chromosome-breaking agents, such as acute radiation or certain chemicals.

What causes a deletion mutation?

A deletion mutation occurs when a wrinkle forms on the DNA template strand and subsequently causes a nucleotide to be omitted from the replicated strand (Figure 3). Figure 3: In a deletion mutation, a wrinkle forms on the DNA template strand, which causes a nucleotide to be omitted from the replicated strand.

Can chromosome deletions be fixed?

“When chromosome duplication compensates for the loss of the corresponding ring chromosome with a deletion, this provides a possible avenue to correct large-scale problems in a chromosome that have no chance of being corrected by any other means.”

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