What is norethindrone Mestranol?
MESTRANOL; NORETHINDRONE (MES truh nol; nor eth IN drone) is an oral contraceptive. The products combine two types of female hormones, an estrogen and a progestin. They are used to prevent ovulation and pregnancy.
Is Mestranol a prodrug?
Mestranol is a prodrug of ethinylestradiol in the body. Mestranol was discovered in 1956 and was introduced for medical use in 1957. It was the estrogen component in the first birth control pill.
Is Mestranol water soluble?
Soluble in ethanol, ether, chloroform, dioxane, acetone. Slightly soluble in methanol. Practically insoluble in water.
Which is the 3 methyl ether of mestranol?
Mestranol is the 3-methyl ether of ethinylestradiol. Ethinylestradiol, is a synthetic derivative of estradiol. Ethinylestradiol is orally bio-active and the estrogen used in almost all modern formulations of combined oral contraceptive pills. It binds to (and activates) the estrogen receptor.
What is the mechanism of action of mestranol?
It has a role as a prodrug and a xenoestrogen. It is a 17beta-hydroxy steroid, a terminal acetylenic compound and an aromatic ether. It derives from a 17beta-estradiol. Mestranol is an Estrogen. The mechanism of action of mestranol is as an Estrogen Receptor Agonist.
Why was mestranol replaced by ethinylestradiol in 1969?
As far as the estrogens are concerned, the original estrogen, mestranol, was abruptly replaced by ethinylestradiol in most or all products after a wide-scale panic relating to risk of thrombosis in 1969. The motive lay entirely in the fact that the ethinylestradiol was about twice as potent, so that the dose could be halved.
What kind of estradiol is in mestranol pills?
Mestranol is a synthetic estradiol found in oral contraceptive pills for contraception and the treatment of other conditions in the female reproductive system, such as dysmenorrhea and dysfunctional uterine bleeding. The 3-methyl ether of ethinyl estradiol.