What kind of protein is the AMOT gene?
This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs.
How does AMOTL1 interact with YAP1 and CTGF?
Taken together, AMOTL1 plays an oncogenic role in gastric carcinogenesis through interacting with YAP1 and promoting its nuclear accumulation. A combination of AMOTL1, YAP1, and CTGF expression might serve as a surrogate of Hippo activation status.
What is the clinical significance of AMOTL1 in gastric cancer?
The clinical significance of the AMOTL1–YAP1–CTGF axis in gastric cancer (GC) was analyzed by multiple clinical cohorts. Moreover, the therapeutic effect of targeting the oncogenic axis was appraised by drug-sensitivity tests and xenograft-formation assays.
What kind of diseases are associated with AMOT?
AMOT (Angiomotin) is a Protein Coding gene. Diseases associated with AMOT include Papilloma and Nasal Cavity Benign Neoplasm . Among its related pathways are Adhesion and Cytoskeletal Signaling .
Angiomotin (AMOT) is a protein that in humans is encoded by the AMOT gene. It belongs to the motin family of angiostatin binding proteins, which includes angiomotin, angiomotin-like 1 ( AMOTL1) and angiomotin-like 2 ( AMOTL2) characterized by coiled-coil domains at N-terminus and consensus PDZ -binding domain at the C-terminus.
What are the two splice isoforms for angiomotin?
Two splice isoforms are known for angiomotin: p80 and p130. The alternative splicing is somewhat tissue specific. Cells expressing p130 contained more actin than those expressing p80. p80 is not the product of cleavage of p130, as p130 contains no potential proteolytic cleavage site for such conversion.
When was the discovery of angiomotin made?
Discovery. Angiomotin was discovered in 2001 by screening a placenta yeast two-hybrid cDNA library for angiostatin-binding peptides, using a construct encoding the kringle domain s 1-4 of angiostatin.
Where does angiomotin p80 bind on the cell surface?
Angiomotin p80 locates and binds angiostatin on the cell surface. In primary endothelial of Chinese hamster ovary, it localizes to cell-cell junction, recruits ZO-1 and interacts with MAGI-1. It may play a role in the assembly of endothelial cell-cell junctions, as well.