What is a granuloma inguinale?

What is a granuloma inguinale?

Granuloma inguinale (donovanosis) is a genital ulcerative disease caused by the intracellular gram-negative bacterium Klebsiella granulomatis (formerly known as Calymmatobacterium granulomatis).

How is granuloma inguinale diagnosed?

To confirm the diagnosis of granuloma inguinale, doctors take a sample of fluid scraped from the sore and examine it under a microscope. If the diagnosis is unclear, doctors take a sample of tissue and examine it under a microscope (biopsy).

What are the signs and symptoms of granuloma inguinale?

Symptoms

  • Sores in the anal area in about half of the cases.
  • Small, beefy-red bumps appear on the genitals or around the anus.
  • The skin gradually wears away, and the bumps turn into raised, beefy-red, velvety nodules called granulation tissue.
  • The disease slowly spreads and destroys genital tissue.

Can granuloma inguinale be cured?

Granuloma inguinale can be treated using antibiotics like tetracycline and the macrolide erythromycin. Streptomycin and ampicillin may also be used. Most treatments are prescribed for three weeks, although they will continue until the infection is cured.

What type of STI is Donovanosis?

What is donovanosis? Donovanosis is caused by a bacterium called Klebsiella granulomatis. Like other types of STIs, donovanosis is transmitted via vaginal, anal, and oral sex. Donovanosis has been called the “flesh-eating STD” because it causes thick, ulcer-like sores that can eventually damage genital tissues.

What are the complications of granuloma inguinal?

Complications of chronic granuloma inguinale include bleeding, secondary infection, swelling from lymphoedema, and significant scarring causing destruction of the genital architecture.

Are Chancroids painful?

Chancroid is caused by the bacterium Haemophilus ducreyi and results in painful, superficial ulcers, often with regional lymphadenopathy. Chancroid occurs in Asia, Africa, and the Caribbean, and is an important cofactor of HIV transmission. The genital ulcer from chancroid is painful, tender, and nonindurated.

Who is at risk for granuloma?

Who is at risk of granuloma inguinale? Sexually active people are at risk of getting granuloma inguinale. The peak incidence is between 20 and 40 years of age. Vertical transmission during childbirth can also occur from contact with the bacteria in the genital tract.

What are the common signs and symptoms of Donovanosis?

Signs and symptoms of donovanosis include one or more painless lumps, usually in the genitalia, anal region or groin. The lump(s) slowly gets larger and then ulcerates. These sores typically bleed easily, have a rolled edge and are beefy-red in colour. In some cases the sore has an offensive smell.

Does granuloma inguinale cause lymphadenopathy?

Extragenital involvement Lymphadenopathy does not occur as a result of the primary infection with Klebsiella granulomatis, but, rather, it occurs from secondary bacterial infections. Pseudobuboes resemble lymph nodes, but they are just nodular lesions.