What is a NOD SCID mice?
The NSG mouse (NOD scid gamma mouse) is a brand of immunodeficient laboratory mice, developed and marketed by Jackson Laboratory, which carries the strain NOD. NSG branded mice are among the most immunodeficient described to date. NSG branded mice lack mature T cells, B cells, and natural killer (NK) cells.
Are NOD SCID mice diabetic?
As outlined in a recent post, NOD-scid mice (NOD. CB17-Prkdcscid/J), because they are B and T cell-deficient, do not develop diabetes.
Are NOD SCID mice transgenic?
Although transgenic NOD mice develop diabetes significantly earlier than do NOD/ShiLtDvs (NOD) mice, this transgenic strain harbors the Prkdcscid mutation (characterized by an absence of functional T cells and B cells) and therefore does not become diabetic.
Are NSG mice CD45 1 or CD45 2?
Because leukocytes derived from NSG and donor mice differ in their CD45 allele (recipients express CD45. 1, donors express CD45. 2), cell origins can be readily distinguished by cell-surface staining.
What does SCID stand for?
Severe combined immunodeficiency (SCID) is a group of rare disorders caused by mutations in different genes involved in the development and function of infection-fighting immune cells. Infants with SCID appear healthy at birth but are highly susceptible to severe infections.