Where does Cholangiocellular carcinoma occur?
Cholangiocarcinoma is a type of cancer that forms in the slender tubes (bile ducts) that carry the digestive fluid bile. Bile ducts connect your liver to your gallbladder and to your small intestine.
How is CCA diagnosed?
A diagnosis of CCA is suspected based upon a thorough clinical evaluation and identification of characteristic findings. A diagnosis may be confirmed by molecular genetic testing which detects FBN-2 gene mutations in approximately 75 percent of patients. CCA has also been recognized via prenatal ultrasound.
What is iCCA cancer?
iCCA is the second-most common primary liver cancer; its incidence has increased by 22% between 1979 and 2004. The increased incidence, which only partially can be explained by more frequent diagnosis and greater awareness, has been accompanied by a 39% increase in mortality.
What causes elongated fingers?
Longer arms in Marfan syndrome Marfan syndrome is a genetic disorder that causes people to have unusually long arms, legs and fingers.
How common is Arachnodactyly?
The prevalence of congenital contractural arachnodactyly is estimated to be less than 1 in 10,000 worldwide.
What is difference between adenocarcinoma and cholangiocarcinoma?
Adenocarcinomas, the most common type of extrahepatic bile duct cancer, form in the cells of the mucous gland lining the inside of the bile duct. Adenocarcinomas account for about 95 percent of all bile duct cancers. Bile duct adenocarcinoma is also called cholangiocarcinoma.
What is the ICD O code for cholangiocarcinoma?
Cholangiocarcinoma (CC; ICD-O code: 8160/3; also called bile duct carcinoma and bile duct adenocarcinoma) is a term which encompasses a heterogeneous group of malignant tumors with pathological features of biliary tract differentiation, distinct from gallbladder cancer.
What kind of cancer is a cholangiocarcinoma?
Cholangiocarcinomas (CCAs) are a heterogenous group of tumors that arise from the cholangiocytes that line the biliary tree. CCAs are classified based on their anatomic location, as follows: (1) intrahepatic CCA (iCCA), (2) perihilar CCA (pCCA), or (3) distal CCA (dCCA) (Figure 1).
Which is the best staging system for cholangiocarcinoma?
Cholangiocarcinoma (staging) Cholangiocarcinoma staging is most commonly classified using the TNM staging systems of the American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC), which starting January 1, 2018 is according to its 8 th edition.
Can a Bilin lesion be a precursor of cholangiocarcinoma?
In specimens of bile ducts from patients with hepatolithiasis, biliary intraepithelial neoplasia (BilIN) is a common finding and is considered to be a precursor lesion of cholangiocarcinoma. It is typically a microscopic lesion with a flat or micropapillary dysplastic epithelium.