What are lipid-laden histiocytes?
Abstract. In addition to granulomas, infiltrates of pigmented, lipid-laden histiocytes are a consistent morphologic finding in visceral organs of the reticuloendothelial system in patients with chronic granulomatous disease.
Are there resident macrophages in the lungs?
Lung-resident macrophages and dendritic cells are located in close proximity to the epithelial surface of the respiratory system and the capillaries to sample and examine the air-borne and blood-borne material.
What are fat laden cells?
Foam cells, also called lipid-laden macrophages, are a type of cell that contain cholesterol. These can form a plaque that can lead to atherosclerosis and trigger heart attacks and stroke. Foam cells are fat-laden M2 macrophages containing low density lipoproteins (LDL).
What macrophages are found in the lungs?
In the lung, there are two distinct macrophage populations: alveolar macrophages, which are in close contact with the type I and II epithelial cells of alveoli (1); and interstitial macrophages, which reside in the parenchyma between the microvascular endothelium and alveolar epithelium (2).
What causes lipid laden macrophages?
Increased levels of lipid-laden alveolar macrophages are associated with various respiratory conditions, including chronic smoking, gastroesophageal reflux, lipoid pneumonia, fat embolism, pulmonary alveolar proteinosis and pulmonary aspiration.
Which cell is respiratory macrophage?
In a healthy lung, there are at least two types of macrophages: alveolar macrophages (AM) and interstitial macrophages (IM) . They are functionally different and can be distinguished by localization within the lung and expression of CD11b and CD11c.
Where are alveolar macrophages found?
Alveolar macrophages are mononuclear phagocytes found in the alveoli of the lungs. They ingest small inhaled particles resulting in the degradation, clearance and presentation of the antigen to adaptive immune cells.
What causes lipid-laden macrophages?
What does pigment laden macrophages mean?
Pigment-laden macrophages within the airspaces are most commonly related to cigarette smoking or hemosiderin. Both smoker’s macrophages and hemosiderin-laden macrophages are positive on iron stains; misinterpretation is common.