Why vidarabine was discontinued?
Vidarabine is no longer used due to toxicity issues as well as the discovery of more potent and safer compounds such as Acyclovir, which today is widely prescribed for HSV (Hamann et al., 2007).
What does vidarabine treat?
VIRA-A is the trade name for vidarabine (also known as adenine arabinoside and Ara-A), an antiviral drug for the topical treatment of epithelial keratitis caused by Herpes simplex virus.
Is valtrex the same as acyclovir?
(Acyclovir itself is available as a topical, oral, and intravenous medication.) Valtrex thus is active against the same viruses as acyclovir, but Valtrex has a longer duration of action than acyclovir and can be taken fewer times each day.
What is the use of Vira?
Vira-A (vidarabine monohydrate) Ophthalmic Ointment is an antiviral medication used to treat eye infections caused by the herpes virus. The brand name Vira-A is discontinued, but generic versions may be available. Common side effects of Vira-A (vidarabine monohydrate) include: burning.
Where does Vidarabine come from?
1. Vidarabine or Ara-A. In 1950, Bergmann et al. [6] isolated from the Caribbean sponge Tethya crypta (Tethylidae) the nucleosides spongothymidine and spongouridine, which contained an arabinose sugar rather than the more common ribose sugar found in these nucleosides.
Is Vidarabine a nucleoside analog?
Vidarabine Anhydrous is an anhydrous form of vidarabine, a nucleoside analog with activity against herpes simplex virus and varicella zoster virus. Vidarabine is converted to a monophosphate by viral thymidine kinase and is further modified to a triphosphate form by host enzymes.
What is the source of vidarabine?
Discovery. In the 1950s two nucleosides were isolated from the Caribbean sponge Tethya crypta: spongothymidine and spongouridine; which contained D-arabinose rather than D-ribose. These compounds led to the synthesis of a new generation, sugar modified nucleoside analog vidarabine, and the related compound cytarabine.
Is vidarabine a nucleoside analog?
Is there anything stronger than acyclovir?
Studies show that a small 500 mg dose of valacyclovir is as effective as a larger 800 mg dose of acyclovir in treating HSV.
What does Vira mean?
brave person
Vira is a Sanskrit word that means “brave person” or “hero.” The root word, vir, means “to overpower.”
What is tadalafil 20 mg used for?
About tadalafil Tadalafil is a medicine used to treat erection problems (erectile dysfunction) and symptoms of an enlarged prostate (benign prostate enlargement). It’s also sometimes used to treat pulmonary hypertension (high blood pressure in the blood vessels that supply the lungs).