Does indole-3-carbinol reduce estrogen?
I3C decreases estrogen-driven luciferase activity. Treatment with genistein results in an even greater decrease. Treatment with the two phytochemicals reduces expression significantly more than would have been predicted if the effect of the two phytochemicals were additive, which indicates a clearly synergistic effect.
Does indole-3-carbinol increase testosterone?
According to our results, several steroid hormones (estradiol, estrone sulphate and androstenedione) were significantly increased in I3C treated tumor homogenates while testosterone was diminished. Interestingly, testosterone was significantly increased in the sera of I3C treated mice.
Does indole-3-carbinol really work?
Cancer Prevention 1 Lab studies also suggest that I3C may improve the effectiveness of chemotherapy treatments. In early clinical trials, evidence suggests that I3C may reduce female breast cancer risk in some people and help eliminate precancerous cervical cells caused by the human papillomavirus (HPV).
Do indoles increase estrogen activity?
Indole-3-carbinol (I3C), a compound occurring naturally in cruciferous vegetables, exhibits a potent antitumor activity via its regulation of estrogen activity and metabolism.
How do you decrease estrogen levels?
Tips for reducing estrogen levels
- Follow a fiber-rich diet. Studies have shown high fiber diets promote healthy estrogen levels.
- Limit certain animal products.
- Follow a Mediterranean-style diet.
- Lose excess body fat.
- Limit refined carbs and processed foods.
- Exercise.
- Limit alcohol intake.
Does DIM affect progesterone?
(26) This new nutritional approach to PMS helps with mineral and hormonal balance. DIM works in conjunction with chasteberry extract to resolve the dominance of estrogen over progesterone.
Does Diindolylmethane block estrogen?
Diindolylmethane might act like estrogen in the body, but there is evidence that under certain circumstances it might also block estrogen effects. Diindolylmethane also appears to help destroy cancer cells and reduce swelling.
Which is adverse effect of indoles?
It can cause side effects such as skin rashes and diarrhea. In higher doses, indole-3-carbinol can cause balance problems, tremor, and nausea.
Does I3C increase estrogen?
Epidemiological, laboratory, animal and translational studies support the efficacy of I3C. Whereas estrogen increases the growth and survival of tumors, I3C causes growth arrest and increased apoptosis and ameliorates the effects of estrogen.
How much I3C should I take?
Dosage. One or two servings per day is the recommended intake. In supplement form, 400 mg/day of indole-3 carbinol (I3C) is recommended. One head of cabbage contains approximately 1200 mg of indole-3-carbinol.
What is indole 3 butyric acid used for?
Indole-3-butyric acid is a substance that is closely related in structure and function to a natural growth regulator found in plants. Indole-3-butyric acid is used on many crops and ornamentals to promote growth and development of roots, flowers and fruits, and to increase crop yields.
How is indole-3-carbinol an effective estrogen blocker?
Indole-3-carbinol and testosterone – an effective estrogen blocker Testosterone is tightly regulated in 3 different ways: Direct testosterone production by the Leydig cells of the testes. Indirect stimulation of the Leydig cells by the brain via luteinizing hormone.
How does indole 3 carbinol affect testosterone levels?
Indole-3-carbinol is a plant-based compound believed to ameliorate a number of illnesses. Research has also shown it may indirectly increase testosterone levels by: Blocking aromatase. I3C may maintain testosterone levels by limiting its conversion into estrogen. Anti-estrogenic effects.
What are the benefits of indole 3 carbinol?
The main benefit linking indole-3-carbinol to testosterone levels is that it acts as a potent anti-estrogenic, shown in numerous studies to not only slow down the process of aromatization, but to help eliminate estrogen from the body too.
How does I3C work to maintain testosterone levels?
I3C may maintain testosterone levels by limiting its conversion into estrogen. Anti-estrogenic effects. I3C regulates the production and breakdown of estrogen, and one of the potential results of this process is to “free” bound testosterone.