How is oxytocin a tocolytic?
Oxytocin receptor antagonists (OTR-A) have been developed as tocolytics for the management of preterm labour due to the significant role of oxytocin (OT) in the onset of both term and preterm labour. Similar to OT, prostaglandins (PGs) play key roles in myometrial contractility and cervical ripening.
What class of drug is Atosiban?
G02CX01 – atosiban ; Belongs to the class of other gynecologicals. Used to inhibit uncomplicated premature labour between 24 and 33 weeks of gestation.
Is Atosiban used for medical abortion?
Atosiban, sold under the brand name Tractocile among others, is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor.
How do you give tractocile?
Tractocile is given into a vein in three stages, over a maximum of 48 hours: an initial injection into a vein (6.75 mg), followed by a high-dose infusion (18 mg per hour) over three hours, then a lower dose infusion (6 mg per hour) lasting up to 45 hours.
What is the action of Tocolytics?
Tocolytic agents are drugs designed to inhibit contractions of myometrial smooth muscle cells. Such an effect has been demonstrated in vitro or in vivo for several pharmacological agents, including beta-adrenergic agonists, calcium channel antagonists, oxytocin antagonists, NSAIDs and magnesium sulfate.
How do you administer Atosiban?
Atosiban accord injection is administered intravenously in three successive stages: an initial bolus dose (6.75 mg), performed with Atosiban 6.75 mg/0.9 ml solution for injection, immediately followed by a continuous high dose infusion (loading infusion 300 micrograms/min) of Atosiban accord injection 37.5 mg/5 ml …
What is Atosiban IVF?
It can be defined as a failure to achieve implantation in at least three consecutive IVF attempts when 1–2 high quality embryos were transferred in each cycle [6]. Atosiban is a receptor antagonist for vasopressin V1a and oxytocin.
Is Atosiban safe in pregnancy?
Conclusions: Administration of atosiban has a comparatively better effect than that of ritodrine on pregnant women who underwent ART and is safe and effective at preventing immediate preterm birth.
How do you get fetal fibronectin?
For fetal fibronectin testing, a sample of fluid is collected from the vagina or the opening to the uterus (cervix). First, a speculum is used to spread the walls of the vagina to view the cervix. Next, a sterile swab is used to absorb fluid from the cervix or vagina.
Which is the active substance in the Tractocile?
The active substance in Tractocile, atosiban, is an antagonist of the natural hormone oxytocin. This means that atosiban blocks the action of oxytocin. Oxytocin is the hormone involved in starting contractions of the womb.
How is Tractocile used in pre term Labour?
The ability of Tractocile to delay pre-term birth was studied in 742 women who were 23 to 33 weeks pregnant in three main studies. Tractocile was compared with ritodine, terbutaline and salbutamol (all from a different class of medicines used in pre-term labour called beta-agonists).
How does the hormone Tractocile work in the womb?
Oxytocin is the hormone involved in starting contractions of the womb. By blocking the action of oxytocin, Tractocile prevents contractions and causes the womb to relax, helping to delay birth. How has Tractocile been studied?
How long does it take to take Tractocile?
Tractocile is given into a vein in three stages, over a maximum of 48 hours: an initial injection into a vein (6.75 mg), followed by a high-dose infusion (18 mg per hour) over three hours, then a lower dose infusion (6 mg per hour) lasting up to 45 hours.