What is CD56 a marker for?
CD56, or neural cell adhesion molecule (NCAM), has been demonstrated recently as the tumor marker of the pulmonary neuroendocrine cell system.
What does CD56 positive mean?
Tumors that are CD56 positive are Myeloma, Myeloid Leukemia, Neuroendocrine tumors, Wilm’s Tumor, Adult Neuroblastoma, NK/T cell Lymphomas, Pancreatic Acinar-cell Carcinoma, Pheochromocytoma, and Small-cell Lung Carcinoma. It is also expressed on some mesodermally-derived tumors (Rhabdomyosarcoma).
What is CD56 negative?
Natural killer cells lacking expression of CD56 (CD56neg NK cells) have been described in chronic HIV and hepatitis C virus infection. Features and functions of CD56neg NK cells in the context of latent infection with CMV and / or EBV with age are not known.
What CD56 bright?
CD56bright NK cells produce abundant cytokines (e.g., IFN-γ) (3) and have immunoregulatory function (4), whereas CD56dim play a key role in natural and Ab-mediated cell cytotoxicity (2, 5). The phylogeny and ontogeny of these human NK subsets are poorly understood.
What do CD56 cells do?
Also, in the bone marrow, at the site where hematopoiesis occurs, CD56 fulfills a pivotal role. Mesenchymal stromal cells provide niches for hematopoietic stem cells by, inter alia, the expression of adhesion molecules comprising CD56, maintaining long-term hematopoiesis (7, 8).
Do B cells express CD56?
CD56 (NCAM), a neural adhesion molecule, is normally expressed on natural killer cells and subsets of T cells and is commonly seen on hematolymphoid neoplasms such as plasma cell myeloma and acute myelogenous leukemia. These CD56 B-cell lymphomas may represent a new subset of large B-cell lymphoma.
Do T cells have CD56?
CD56 is a homologue of neural cell adhesion molecule present on most natural killer (NK) cells and also a small subpopulation of T cells. T cells expressing CD56 have been variously referred to as CD3+ CD56+ cells,3 NK-like T cells4 and cytokine-induced killer cells.
What is CD16 and CD56?
The high expression level of CD16 makes them efficient mediators of antibody-dependent cellular cytotoxicity, whereas CD56bright CD16dim NK cells perform antibody-dependent cellular cytotoxicity only weakly and CD56bright CD16− NK cells of course not at all.
Do T cells express CD56?
What are CD45RA cells?
CD45RA T cells have “naive” characteristics of unresponsiveness to recall antigens and prominence in cord blood, while CD45RO T cells are considered “memory” T cells because they proliferate to recall antigens and increase following PHA activation of cord blood.