What is the human analog for the DAF 18 gene?
daf-18 encodes a homolog of the human tumor suppressor PTEN (MMAC1/TEP1), which has 3-phosphatase activity toward phosphatidylinositol 3,4,5-trisphosphate (PIP3).
How many genes does C. elegans have?
The number of genes predicted for the Caenorhabditis elegans genome is remarkably high: approximately 20,000, if both protein-coding and RNA-coding genes are counted.
What is special about the nematode C. elegans?
It was the first multicellular organism to have its whole genome sequenced, and as of 2019, is the only organism to have its connectome (neuronal “wiring diagram”) completed.
How are C. elegans strains named?
elegans gene is identified in a related species such as Caenorhabditis briggsae, it can be given the same gene name, preceded by two italic letters referring to the species, and a hyphen. For example, Cb-tra-1 is the name for the C. briggsae homolog of the C. elegans gene tra-1 .
What is DAF 18 gene?
daf-18 encodes a homolog of the human tumor suppressor PTEN (MMAC1/TEP1), which has 3-phosphatase activity toward phosphatidylinositol 3,4,5-trisphosphate (PIP3). DAF-18 PTEN may normally limit AKT-1 and AKT-2 activation by decreasing PIP3 levels.
What is the common name of C. elegans?
Caenorhabditis elegans
Map to
| Mnemonic i | CAEEL |
|---|---|
| Common name i | – |
| Synonym i | – |
| Other names i | ›Caenorhabditis elegans (Maupas, 1900) ›Rhabditis elegans ›Rhabditis elegans Maupas, 1900 ›roundworm |
| Rank i | SPECIES |
What is RAD51C gene?
RAD51C (RAD51 Paralog C) is a Protein Coding gene. Diseases associated with RAD51C include Breast-Ovarian Cancer, Familial 3 and Fanconi Anemia, Complementation Group O. Among its related pathways are Cell Cycle, Mitotic and Homologous DNA Pairing and Strand Exchange.
How does DAF-2 work in C.elegans?
DAF-2/Insulin-Like Signaling in C. elegans Modifies Effects of Dietary Restriction and Nutrient Stress on Aging, Stress and Growth BackgroundDietary restriction (DR) and reduced insulin/IGF-I-like signaling (IIS) are two regimens that promote longevity in a variety of organisms.
What does the DAF-2 gene encode for?
The DAF-2 gene encodes for the insulin-like growth factor 1 (IGF-1) receptor in the worm Caenorhabditis elegans. DAF-2 is part of the first metabolic pathway discovered to regulate the rate of aging.
What does DAF 2 stand for in Worms?
The DAF-2 gene encodes for the insulin-like growth factor 1 (IGF-1) receptor in the worm Caenorhabditis elegans.
How are DAF-16 and DAF 2 receptors related?
By silencing DAF-16, activation of DAF-2 receptors can ultimately compromise a cell’s ability to mitigate harmful environmental conditions. In most eukaryotes, insulin activates DAF-2 signaling. However, both human insulin and insulin coded for by orthologous genes in C. elegans inhibit DAF-2 receptors in C. elegans.