What is simdax used for?
This medicine is used to treat heart failure in people who still find it hard to breathe, even though they are taking other medicines to get rid of extra water from the body. This medicine belongs to a class of medicines called calcium sensitisers. shortness of breath from severe heart failure.
Does levosimendan increase heart rate?
Levosimendan produces significant, dose-dependent increases in cardiac output, stroke volume and heart rate, and decreases in PCWP, mean blood pressure, mean pulmonary artery pressure, mean right atrial pressure and total peripheral resistance.
How to administer levosimendan?
Levosimendan is prepared by diluting one 5ml vial of 2.5mg/ml solution in 500ml of 5% dextrose to make a 0.025mg/ml solution. Administer by infusion only. Do NOT administer a loading dose as this increases the risk of adverse events. Begin the infusion at a rate of 0.05mcg/kg/min (see Dosage table below).
Is levosimendan fda approved?
Although not approved for any use in the United States, levosimendan, a calcium sensitizing inotrope, is commonly used in other countries for treating heart failure and low cardiac output syndrome in patients undergoing cardiac surgery.
How does digoxin work to increase calcium levels and thus cardiac contractility?
Digoxin induces an increase in intracellular sodium that will drive an influx of calcium in the heart and cause an increase in contractility. Cardiac output increases with a subsequent decrease in ventricular filling pressures.
What is a calcium sensitizer?
Calcium sensitizers comprise a new drug class that offers hemodynamic and symptomatic improvements without increasing cAMP and intracellular calcium concentrations.
What is Enoximone used for?
Enoximone (INN, trade name Perfan) is an imidazole phosphodiesterase inhibitor. It is used in the treatment of congestive heart failure and is selective for phosphodiesterase 3.
Is levosimendan an Inotrope?
Levosimendan, a new calcium-sensitizing inotrope for heart failure. Pharmacotherapy.
When do you take levosimendan?
Levosimendan should be used with caution and with tightened haemodynamic monitoring in patients who have low baseline blood pressure (systolic blood pressure <100 mmHg; diastolic blood pressure <60 mmHg), or who are at risk of a hypotensive episode.
Is levosimendan available in India?
5 mL Levosimendan Injection, for Clinic and Hospital, Rs 180 /unit | ID: 14715508912.
Who makes levosimendan?
Orion Corporation
Levosimendan (INN) /ˌliːvoʊsaɪˈmɛndən/ is a calcium sensitizer used in the management of acutely decompensated congestive heart failure. It is marketed under the trade name Simdax (Orion Corporation). Overall the drug has a two fold mechanism of action.