How do you reconstitute ganciclovir?
Reconstitute vial with 10 ml of Sterile Water for Injection (do not use bacteriostatic water), and shake well to dissolve drug. Vial stability: stable at room temperature for 12 hours (Do not refrigerate). Remember when further diluted with NS or D5W, final solution should be refrigerated until ready for use.
How do you administer ganciclovir IV?
The drug should be given as a constant intravenous injection over a minimum of 1 hour. Each dose of ganciclovir is put in 100 or 250 mL bags. The I.V. solution should be warmed up to room temperature before administration.
How long is ganciclovir induction?
Induction Dosage: The recommended initial dosage of GANCICLOVIR INJECTION for patients with normal renal function is 5 mg/kg (given intravenously at a constant rate over 1 hour) every 12 hours for 14 to 21 days.
Is ganciclovir an antibiotic?
Ganciclovir, sold under the brand name Cytovene among others, is an antiviral medication used to treat cytomegalovirus (CMV) infections.
What is the difference between acyclovir and ganciclovir?
Ganciclovir is a nucleoside analog that differs from acyclovir by a single carboxyl side chain. This structural change confers approximately 50 times greater activity than acyclovir against CMV. Acyclovir has low activity against CMV because it is not well phosphorylated in CMV-infected cells.
Is ganciclovir toxic?
Ganciclovir is known to have hematological toxicity, neurotoxicity, and possibly hepatotoxicity (21). Hematological toxicity has been characterized in vitro on normal human hematopoietic progenitor cells.
In which condition ganciclovir is preferred over acyclovir?
Ganciclovir 0.15% gel is the most recently approved topical treatment for herpes keratitis. Compared to acyclovir 0.3% ointment, ganciclovir 0.15% gel has been shown to be better tolerated and no less effective in several Phase II and III trials.
Should ganciclovir be taken with food?
It is important that you take ganciclovir capsules with food. This is to make sure the medicine is fully absorbed into the body and will work properly. To get the best results, ganciclovir must be given for the full time of treatment. Also, this medicine works best when there is a constant amount in the blood.
Is Valganciclovir the same as ganciclovir?
Valganciclovir, an oral prodrug that is rapidly converted to ganciclovir, also plays a major role in the treatment and prevention of CMV infections in immunocompromised hosts.
Is ganciclovir an immunosuppressant?
Ganciclovir is an antiviral medication used to prevent or treat infections caused by Cytomegalovirus (CMV). Liver transplant recipients are susceptible to CMV due to immunosuppressant drugs. Ganciclovir will not cure CMV eye infection, but it may help prevent the symptoms from becoming worse.
Is ganciclovir a chemo?
Conclusions: Ganciclovir is the only antiviral chemotherapy which reduces the risk of CMV infection or disease after most types of major transplantation.
In which condition Ganciclovir is preferred over acyclovir?