What causes no reflow?
In summary, the cause of no-reflow can be classified into four main pathogenetic components: distal athero-thrombotic embolization, ischemia-related and/or reperfusion-related injury, as well as the susceptibility of coronary microcirculation to injury.
What is no reflow after PCI?
“Reperfusion no reflow” occurs after primary percutaneous coronary intervention (PCI) for reperfusion of an infarct artery in the setting of acute myocardial infarction (AMI) and may be asymptomatic or may present clinically with continued chest pain and ST-segment elevation.
What is no reflow phenomenon?
When a coronary artery is occluded, detrimental changes occur in the cardiac capillaries and arterioles. After relief of the occlusion, blood flow to the ischemic tissue may still be impeded, a phenomenon known as no reflow.
Why is PCI non surgical?
Percutaneous Coronary Intervention (PCI, formerly known as angioplasty with stent) is a non-surgical procedure that uses a catheter (a thin flexible tube) to place a small structure called a stent to open up blood vessels in the heart that have been narrowed by plaque buildup, a condition known as atherosclerosis.
What should I do after PCI?
You may remove the bandage 1 day after your Percutaneous Coronary Intervention (PCI). You may shower 1 day after your PCI. Do Not sit upright for more than 1 hour at a time during the first day at home. If traveling for long periods, stretch your legs out and get up and walk every hour during the first day going home.
Can perfusion cause cell necrosis?
Shock occurs as a result of inadequate tissue perfusion; the lack of an adequate energy supply leads to the buildup of waste products and failure of energy-dependent functions, release of cellular enzymes, and accumulation of calcium and reactive oxygen species (ROS) resulting in cellular injury and ultimately cellular …
How does ischaemia cause cell injury?
Ischemic injury causes a calcium influx into cells (through glutamate receptors), which then mediate excitotoxic cell death.
When do you see contraction band necrosis?
Contraction band necrosis is a type of uncontrolled cell death (necrosis) unique to cardiac myocytes and thought to arise in reperfusion from hypercontraction, which results in sarcolemmal rupture. It is a characteristic histologic finding of a recent myocardial infarction (heart attack) that was partially reperfused.
What are contraction bands in MI?
Contraction bands are associated with reperfusion. In myocardial infarction, they are most likely seen at margin of infarct. They can also be seen in cases of sudden cardiac death and perioperative ischemia during cardiac surgery. They represent hypercontraction due to massive calcium influx.