How does memantine affect glutamate?
Memantine blocks this receptor and thereby decreases the effects of glutamate. It is thought that by blocking the NMDA receptor and the effects of glutamate, memantine may protect nerve cells from excess stimulation by glutamate.
Why does memantine block glutamate?
Memantine binds weakly to the ion channel-binding site on the NMDA receptor when it is in an open state and thus blocks the tonic pathological activation, induced by micromolar glutamate concentrations.
What is the difference between Namenda and memantine?
Namenda (also called Memantine) was approved by the FDA in 2003 for use in people with “moderate to severe” Alzheimer’s disease or other types of dementia.
Does memantine decrease glutamate?
Memantine is not believed to act by reducing levels of glutamate or by preventing its release; rather, it is believed to reduce glutamate’s neurotoxic effect by blocking the N-methyl-D-aspartate (NMDA) receptor, thereby preventing the entry of excess calcium[14].
What is Namenda and what are the side effects?
Namenda (memantine) reduces the actions of chemicals in the brain that may contribute to the symptoms of Alzheimer’s disease.
When was Namenda approved for use in Alzheimer’s disease?
Namenda (also called Memantine) was approved by the FDA in 2003 for use in people with “moderate to severe” Alzheimer’s disease or other types of dementia.
Are there any studies on Namenda and Aricept?
Study two (MEM-MD-02) assessed the effect of Namenda in combination with Aricept (donepezil) , a drug used to treat mild to moderate dementia caused by Alzheimer’s disease.
Is there a difference in Adas scores with Namenda?
Study one (MRZ 9605) showed a significant improvement by study’s end in ADAS-ADL scores in patients treated with Namenda compared to those treated with placebo, and a highly significant difference in SIB scores.