What is a prodrug quizlet?
prodrug. A pharmacologically inactive compound that is converted into an active drug by a metabolic biotransformation BUT doesn’t have to be an enzymatic process. soft drugs. aka antedrugs; have a metabolizable functional group; active already; designed to have a predictable and controllable metabolism.
What is a prodrug Mcq?
This set of Drug Biotechnology Multiple Choice Questions & Answers (MCQs) focuses on “Prodrugs – Types”. Explanation: A prodrug is a chemically manufactured inert drug precursor which in biotransformation will give the pharmacologically active drug compound.
What is a prodrug vs active drug?
Drugs can be metabolized by several tissues and organs, such as the kidneys, lungs and intestines, but the main site of metabolism is the liver, which is rich in enzymes. A prodrug is a medication that the body converts into a pharmacologically active drug after it is administered.
What is the purpose of a prodrug?
A prodrug is a compound that has negligible, or lower, activity against a specified pharmacological target than one of its major metabolites. Prodrugs can be used to improve drug delivery or pharmacokinetics, to decrease toxicity, or to target the drug to specific cells or tissues.
Why do we make a prodrug form quizlet?
Terms in this set (13) Nowadays prodrugs are designed to overcome the undesirable physicochemical properties of the active drug, e.g. Smaller dose is required in comparison with ampicillin.
Which of these drugs are prodrugs?
Examples of prodrugs that exist naturally or were produced unintentionally during drug development include aspirin, psilocybin, parathion, irinotecan, codeine, heroin, L-dopa, and various antiviral nucleosides.
Which of these is a prodrug?
What is the prodrug of epinephrine?
Dipivefrin is a prodrug of epinephrine which is hydrolyzed to epinephrine after absorption into the eye.
What is prodrug example?
Prodrug: A precursor (forerunner) of a drug. For example, sulfasalazine is a prodrug. It is not active in its ingested form. It has to be broken down by bacteria in the colon into two products — 5-aminosalicylic acid (5ASA) and sulfapyridine — before becoming active as a drug.
What is prodrug pharmacokinetics?
Prodrug is a pharmacologically inactive derivative of an active drug and undergoes in vivo biotransformation to release the active drug by chemical or enzymatic cleavages. [1,2,3] A prodrug strategy is typically used when a pharmacologically active drug has poor solubility or permeability.
Which one is an example of prodrug?
What is prodrug and example?
Which is the best definition of a prodrug?
A prodrug can be defined as a drug substance that is inactive in the intended pharmacological actions and is must to be converted into the pharmacologically active agent by metabolic or physico-chemical transformation.
What’s the difference between an active and inactive prodrug?
Compound that is metabolized into a pharmacologically active drug. A prodrug is a medication or compound that, after administration, is metabolized (i.e., converted within the body) into a pharmacologically active drug. Inactive prodrugs are pharmacologically inactive medications that are metabolized into an active form within the body.
Where are prodrugs found in the human body?
Type II prodrugs are bioactivated extracelluarly, either in the milieu of GI fluids (Type IIA), within the systemic circulation and/or other extracellular fluid compartments (Type IIB), or near therapeutic target tissues/cells (Type IIC), relying on common enzymes such as esterases and phosphatases or target directed enzymes.
Where does the conversion of prodrugs take place?
For Type II prodrugs, the conversion process could either take place extracellularly in the milieu of gastrointestinal fluids (Type IIA), in the systemic circulation and/or other systemic extracellular fluid compartments (Type IIB), or near therapeutical target cells (Type IIC).