What is the purpose of the FeCl3 in this aspirin test?
Iron (III) ion reacts with phenols to form a purple complex. Salicylic acid contains a phenol group, but acetylsalicylic acid does not. Therefore, if you add FeCl3 to an aspirin sample and you see a purple color, it means that there is still some salicylic acid present and the sample is impure.
What is the purpose of the synthesis of aspirin lab?
The purpose of this lab was to synthesize Aspirin and measure the synthesized Aspirin’s purity. By calculating the theoretical yield based on the original amount of Salicylic acid, one could determine the actual yield percentage of the reaction.
How does ferric chloride test work?
Ferric Chloride Test Step 1: Dissolve the sample in water plus ethanol. Step 2: Add drops of a dilute solution of ferric chloride (FeCl3). Step 3: If the sample turns to red, green, purple, or blue colouration then it indicates the presence of phenols.
How do you test for ferric chloride?
How would you test the purity of aspirin prepared in this experiment?
In this experiment the solvent that used to dissolved the impurities is ethyl acetate and then using hot filtration to remove inpurities. The purity of the synthesized acetylsalicylic acid was tested by FeCl3, if there is colour change (violet colour) that means there have impurities in acetylsalicylic acid.
How is aspirin made in a lab?
Aspirin is prepared by chemical synthesis from salicylic acid, through acetylation with acetic anhydride. The molecular weight of aspirin is 180.16g/mol. It is odourless, colourless to white crystals or crystalline powder.
Why is the synthesized aspirin in the laboratory Cannot be used for commercial and pharmaceutical purposes?
In this laboratory activity you will synthesize aspirin, a derivative of salicylic acid. Salicylic acid and its derivatives are antipyretics. Salicylic acid itself is not used for these purposes because it has an irritating effect on the stomach. The most common salicylate used in medicine today is aspirin.
How do you test for pure aspirin?
One simple way to tell whether an organic compound is pure is to measure its melting (or boiling) point. A pure compound melts sharply: if impurities are present it melts slowly (over a range of temperature) and the melting point is lower than that of the pure compound.
How do you test for aspirin?
Acetylsalicylic acid (ASA) is still one of the most commonly used therapeutic agents. Salicylic acid, the major metabolite of ASA, can be detected easily in urine using simple chemical spot tests such as ferric chloride or Trinder’s reagent.
What happens when you add ferric chloride to aspirin?
This shows that both the products were relatively pure. The ferric chloride test was used to compare the salicylic acid, crude aspirin, and purified aspirin. After the addition of the ferric chloride, the salicylic acid solution turned purple, and both the aspirin solutions were yellow.
What kind of test is used to test purity of aspirin?
Ferric chloride was used as a colorimetric test to analysis the purity of aspirin. When FeCl3 was placed into the crude aspirin the solution turned yellow with spots of purple. This indicated that impurities (phenols) were present in the crude aspirin. When we tested the pure aspirin the solution turned yellow.
What was the yield of pure aspirin in the lab?
The actual yield of pure aspirin was 2.863g with a yield of 76%. The percent yield indicates that our synthesis was a success but the yield is low and indicates that some of the aspirin was lost during synthesis.
What was the melting point of the first synthesis of aspirin?
Synthesis of Aspirin. 1.081g of Salicylic acid was obtained after the first synthesis. It was thin, short white crystals and had a melting point range or 154-155 degrees Celsius. 1.600g of aspirin was obtained after the second synthesis. This was a white powder and had a melting point range of 134-135 degrees Celsius.