Which drug is given through intrathecal route of administration?
Currently there are only three medications approved by the US Food and Drug Administration (FDA) for use via the intrathecal route, ie, morphine, ziconotide, and baclofen. Morphine targets opioid receptors within the dorsal horn.
What are intrathecal drugs?
Intrathecal drug administration is the introduction of a therapeutic substance into the cerebrospinal fluid by injection into the subarachnoid space of the spinal cord to bypass the blood-brain barrier. The main indications are for anesthesia and pain management.
What is intrathecal injection used for?
An intrathecal injection can help control pain after surgery. An anesthesiologist injects a single dose of narcotic (opioid) medicine around your spinal cord. One injection will last up to 24 hours after it is given. An intrathecal injection can reduce the amount of other medicines needed to control your pain.
What are the advantages of intrathecal route?
The advantages of intrathecal therapy include better analgesia with fewer side effects and a lower dose of drugs administered as the drug is taken directly to the receptors with a good impact on severe spasticity in adults and children.
What is intrathecal space?
(IN-truh-THEE-kul) Describes the fluid-filled space between the thin layers of tissue that cover the brain and spinal cord. Drugs can be injected into the fluid or a sample of the fluid can be removed for testing.
Is intrathecal and subarachnoid the same?
Intrathecal analgesia is the administration of analgesic drugs (as listed above) directly into the CSF in the intrathecal space. The intrathecal space may also be referred to as the subarachnoid space.
Where is intrathecal?
Also known as the subarachnoid space, the intrathecal space is the fluid-filled area located between the innermost layer of covering (the pia mater) of the spinal cord and the middle layer of covering (the arachnoid mater).
Where is the intrathecal space located?
What is the difference between epidural and intrathecal?
Epidural analgesia is the administration of analgesics into the epidural space. Analgesics can be given either as a single injection or as a continuous infusion via an indwelling catheter. Intrathecal analgesia is the administration of analgesic drugs (as listed above) directly into the CSF in the intrathecal space.
How is intrathecal medication given?
Intrathecal administration is a route of administration for drugs via an injection into the spinal canal, or into the subarachnoid space so that it reaches the cerebrospinal fluid (CSF) and is useful in spinal anesthesia, chemotherapy, or pain management applications.