Can metoprolol cause toxicity?
Taking too much metoprolol can slow down your heart rate and make it difficult to breathe. It can also cause dizziness and trembling. The amount of metoprolol that can lead to an overdose varies from person to person.
What is metoprolol toxicity?
Metoprolol poisoning can induce acute myocardial reinfarction in patients with prior AMI or known coronary artery disease. In other words, metoprolol overdose can trigger myocardial ischaemia and dysrhythmia in patients with coronary artery disease.
What is the antidote for a patient that overdosed on metoprolol?
Conclusion: Poisoning by beta-blockers or CCBs usually produces hypotension and bradycardia, which may be refractory to standard resuscitation measures. For cases of beta-blocker poisoning where symptomatic bradycardia and hypotension are present, high-dose glucagon is considered the first-line antidote.
Can overdose of metoprolol be fatal?
We report the first two documented cases of deliberate metoprolol overdose occurring in the United States, one of which eventually proved fatal. The potentially lethal cardiotoxic effects of this drug are illustrated and correlated with the blood and tissue levels of metoprolol.
Can an overdose of metoprolol cause death?
A beta-blocker overdose can be very dangerous. It can cause death. If the person’s heart rate and blood pressure can be corrected, survival is likely.
How much metoprolol is too much?
Adults—At first, 100 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 400 mg per day. Children—Use and dose must be determined by your doctor.
Can metoprolol prevent sudden cardiac death?
However, not all beta blockers confer equal benefit to patients at risk of sudden cardiac death. Results from various trials suggest that lipophilic beta blockers–such as timolol, metoprolol, propranolol, bisoprolol, and carvedilol–may be more beneficial than hydrophilic beta blockers.
Can you overdose on metoprolol tartrate?
Poisoning due to an overdose of metoprolol may lead to severe hypotension, sinus bradycardia, atrioventricular block, heart failure, cardiogenic shock, cardiac arrest, bronchospasm, impairment of consciousness, coma, nausea, vomiting, cyanosis, hypoglycaemia and, occasionally, hyperkalaemia.
What happens if you take two blood pressure pills by mistake?
“Double dosing on hypertension drugs can be potentially dangerous (even fatal), but most often, there are no significant results,” says Stacy Mitchell Doyle, MD, resident physician of FoodTherapyMD and long-time advocate of plant-based nutritional protocols.
What are the signs of an overdose of metoprolol?
Investigations. Poisoning due to an overdose of metoprolol may lead to severe hypotension, sinus bradycardia, atrioventricular block, heart failure, cardiogenic shock, cardiac arrest, bronchospasm, impairment of consciousness, coma, nausea, vomiting, cyanosis, hypoglycaemia and, occasionally, hyperkalaemia.
What happens if you overdose on metoprolol?
Another major medical issue stemming from overdose of metoprolol is low blood sugar, which usually results in symptoms that include hunger, shakiness and irritability. Patients also may experience cold sweats, weakness and a fast heartbeat.
Can an overdose of metoprolol be fatal?
Patients may notice that they feel tired, dizzy and weak, and they might start wheezing. Heart problems may occur, including a slow or irregular heart rate. Additionally, blood pressure and blood sugar may both drop to dangerous levels, making an overdose of metoprolol fatal in some cases.
When to not give metoprolol?
You should not use metoprolol if you have a serious heart problem (heart block, sick sinus syndrome, slow heart rate), severe circulation problems, severe heart failure, or a history of slow heart beats that caused fainting.