How high is D-dimer in PE?
Our center defines high D-dimer levels as >1.3 µg/ml, but the ROC curve analysis suggested that 1.9 µg/ml was the optimal threshold for the diagnosis of PE in our patient sample.
What is a high D-dimer number?
A normal D-dimer is considered less than 0.50. A positive D-dimer is 0.50 or greater.
When is D-dimer too high?
An elevated D-dimer level is not normal. It’s usually found after a clot has formed and is in the process of breaking down. If you are having significant formation and breakdown of blood clot in your body, your D-dimer may be elevated. A negative D-dimer test means that a blood clot is highly unlikely.
What is best D-dimer value?
In the first study (PE confirmed patients/study population = 134/370), it was reported that the best D-dimer cutoff level for significant PE risk = should be 2.152 mg/L (AUC, 0.69; 95% CI, 0.64–0.74; p < 0.05) [11].
Can a D-dimer level be elevated in normal patients?
However, the D-dimer value can be elevated in a number of other normal physiologic, as well as pathologic states. Hence finding the D-dimer level to be elevated should not be the sole basis for a PE workup.
What is the D-dimer concentration in VTE?
Mean D-dimer concentration (interquartile range) among patients with VTE was 2541 ng/mL (1133-3309 ng/mL) compared with 1030 ng/mL (696-2413 ng/mL) for those patients who had an alternative diagnosis.
What should the D-dimer value be for PE?
However, according to the literature, D-dimer values greater than 500 ng/mL are considered positive.7If the threshold for an elevated D-dimer had been increased to 500 ng/mL in this study of the 217 patients from the D-dimer group, 66 would have had an elevated D-dimer, of whom 5 were diagnosed with a PE.
What do you need to know about D-dimer?
Background: D-dimer is routinely measured as part of the clinical diagnosis algorithms for venous thromboembolism (VTE). In these algorithms, low D- dimer cut-off values are used to generate a dichotomous test result that is sensitive, but very non-specific for VTE.