What is the definition de novo?
From Latin, meaning “from the new.” When a court hears a case de novo, it is deciding the issues without reference to any legal conclusion or assumption made by the previous court to hear the case. Trial de novo occurs when a court decides all issues in a case, as if the case was being heard for the first time.
Which is an example of a de novo mutation?
Germline de novo genetic alterations have been implicated in human disease for decades. Virtually all disease-causing aneuploidies arise as de novo events. The best known example for this is trisomy 21, identified in 1959 as the cause of Down syndrome [24].
What causes a de novo mutation?
Germline de novo mutations (DNMs) are genetic changes in the individual caused by mutagenesis occurring in parental gametes during oogenesis and spermatogenesis.
What is the meaning of de novo synthesis?
De novo synthesis refers to the synthesis of complex molecules from simple molecules such as sugars or amino acids, as opposed to recycling after partial degradation. De novo is a Latin phrase, literally translating to “from the new”, but implying “anew”, “from scratch”, or “from the beginning.”
What does de novo mean medical term?
At least, de novo means “new” when applied to coronary-artery lesions. According to Gregory Curfman MD, cardiologists use the phrase to describe a lesion that develops in a new location after bypass surgery or balloon angioplasty has been used to treat earlier lesions.
What is de novo infection?
De novo infection of hepatitis B virus (HBV) occurs after liver transplantation from donors with HBV markers that suggest past infection. In the present study, the complete nucleotide sequences of HBV derived from a donor and recipients were determined to determine the clinical and virological characteristics.
How many de novo mutations are there?
As part of the 1000 Genomes project, the genomes of two parent–offspring trios were sequenced using LCL-derived DNA2. In one of the trios, the authors identified and validated 643 de novo mutations in cell line DNA that were not observed in DNA derived from uncultured blood of these individuals.
How do de novo genes arise?
De novo gene birth is the process by which new genes evolve from DNA sequences that were ancestrally non-genic. De novo genes represent a subset of novel genes, and may be protein-coding or instead act as RNA genes.
What is de novo enzyme?
Abstract. The Rosetta de novo enzyme design protocol has been used to design enzyme catalysts for a variety of chemical reactions, and in principle can be applied to any arbitrary chemical reaction of interest.
What is de novo expansion?
newly chartered bank, as opposed to a bank acquired through a purchase acquisition or a newly opened branch banking office. State interstate banking laws have permitted banking expansion only through holding company acquisitions, rather than de novo charters of new banks.
What does de novo mean in genetics?
De novo may also refer to: De novo, mutation, an alteration in a gene that is present for the first time in one family member as a result of a mutation in a germ cell (egg or sperm) of one of the parents or in the fertilized egg itself.
Are de novo mutations inherited?
De novo mutations are genetic mutations that occur when a sperm or egg is being made. They aren’t inherited from a parent, but end up in every cell of the resulting person. De novo mutations can and do occur as recessive mutations too.
What diseases are caused by gene mutations?
Generally, genetic disorders that are caused by mutations in single genes include cystic fibrosis, Marfan syndrome, and sickle cell anemia. These genetic disorders occur in approximately one of 200 births, and are referred to as monogenetic disorders.
What are genetic mutations?
genetic mutation – (genetics) any event that changes genetic structure; any alteration in the inherited nucleic acid sequence of the genotype of an organism. chromosomal mutation, mutation. genetic science, genetics – the branch of biology that studies heredity and variation in organisms.