What is progression-free survival rate?
Progression-free survival (PFS) is defined as the time from random assignment in a clinical trial to disease progression or death from any cause.
What is the difference between progression-free survival and overall survival?
Progression-free survival (PFS), the time from treatment initiation until disease progression or worsening, may be used as a direct or surrogate measure of clinical benefit for drug approvals, depending on the disease and response observed, while overall survival (OS), the duration of patient survival from the time of …
What is PFS endpoint?
Progression-free survival (PFS) is increasingly used as an important and even a primary endpoint in cancer clinical trials for patients with solid tumors.
What is PFS vs OS?
In some trials, researchers set out to look at progression-free survival (PFS), a measure of how long someone is on a treatment before their cancer starts to grow. They can also look at overall survival (OS), or how long someone lives after starting on a treatment.
What percentage of chemo patients survive?
Five years after treatment, 47% of those who got chemo were still alive. The five-year survival rate was 39% among those who did not undergo chemo.
Are there differences between progression free survival relapse free survival and recurrence free survival?
Technically they are the same. Disease- free survival studies notes the time to first documentation of relapse/recurrences mostly for comparing efficacy in trials, and recurrence-free survival studies focuses on the onset of recurrence local/regional or distant after a standard treatment.
What is meant by overall survival rate?
The overall survival rate is often stated as a five-year survival rate, which is the percentage of people in a study or treatment group who are alive five years after their diagnosis or the start of treatment. Also called survival rate.
Is progression free survival a good endpoint?
Compared with os, pfs is an attractive endpoint in clinical trials because it is available earlier, is less influenced by competing causes of death, and is uninfluenced by crossover and subsequent lines of therapy. However, pfs is associated with measurement error and bias.
What is second progression free survival?
PFS2, defined as time from randomization to first occurrence of investigator-assessed disease progression (PSA progression, progression on imaging, or clinical progression) while the patient was receiving first subsequent treatment for prostate cancer, or death from any cause, whichever occurred first, was an …
What is OS in oncology?
The length of time from either the date of diagnosis or the start of treatment for a disease, such as cancer, that patients diagnosed with the disease are still alive. In a clinical trial, measuring the overall survival is one way to see how well a new treatment works. Also called OS.