What is the mode of action of pyrazinamide?

What is the mode of action of pyrazinamide?

Pyrazinamie gets activated to Pyrazinoic acid in the bacilli where it interferes with fatty acid synthase FAS I. This interferes with the bacteriums ability to synthesize new fatty acids, required for growth and replication. Pyrazinamide diffuses into active M.

Which heterocycle is present in the structure of pyrazinamide?

Pyrazinamide is a medication used to treat tuberculosis. For active tuberculosis, it is often used with rifampicin, isoniazid, and either streptomycin or ethambutol. It is not generally recommended for the treatment of latent tuberculosis….Pyrazinamide.

Clinical data
show IUPAC name
CAS Number 98-96-4
PubChem CID 1046

Which Antitubercular drug is pyridine derivative?

1 Pyridine derivatives as antitubercular agents. A series of reduced lipophilic N-benzylic-imidazo[1,2-a]pyridine-carboxamides (IPAs) with various side chains were designed and synthesized as new antitubercular agents.

What is the structure of pyrazinamide?


Is pyrazinamide bactericidal?

Pyrazinamide is bactericidal for M. tuberculosis when organisms are located in an acid environment such as the macrophage. Pyrazinamide exerts maximum effect during the early phase (2 months) of therapy.

Why is pyrazinamide and isoniazid used together?

Rifampin, isoniazid, and pyrazinamide combination is used to treat tuberculosis (TB) infection. It may be taken alone or with one or more other medicines for TB. Rifampin belongs to the class of medicines called antibiotics and works to kill or prevent the growth of bacteria.

What is Antitubercular?

(AN-tee-too-BER-kyoo-LOH-sis) Describes a drug or effect that works against tuberculosis (a contagious bacterial infection that usually affects the lungs).

Which drug is pyridine derivative?


Drug Drug Description
Niceritrol Not Annotated
Nicomorphine Not Annotated
Diodone Not Annotated
Nikethamide A nicotinic acid derivative indicated as a respiratory stimulant.

Why is ethambutol bacteriostatic?

There is evidence that the drug exerts its bacteriostatic activity by virtue of inhibition of arabinosyl transferase, an enzyme that polymerizes arabinose into arabinan and then arabinogalactan, a mycobacterial cell wall constituent. The antimicrobial activity of ethambutol is limited to mycobacteria.

What is pyrazinamide used for?

Pyrazinamide kills or stops the growth of certain bacteria that cause tuberculosis (TB). It is used with other drugs to treat tuberculosis. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.