Does hyperthyroidism affect baby during pregnancy?

Does hyperthyroidism affect baby during pregnancy?

How does hyperthyroidism affect pregnancy? Uncontrolled hyperthyroidism has many effects. It may lead to preterm birth (before 37 weeks of pregnancy) and low birth weight for the baby. Some studies have shown an increase in pregnancy-induced hypertension (high blood pressure of pregnancy) in women with hyperthyroidism.

Why is methimazole contraindicated in pregnancy?

Risk Summary: This drug crosses the placental membrane and can cause fetal harm, especially during the first trimester; studies have shown that the incidence of congenital malformations is greater in babies of mothers whose hyperthyroidism has remained untreated than in those who have been treated with anti-thyroid …

Can carbimazole be given in pregnancy?

Carbimazole must only be administered during pregnancy after a strict individual benefit/risk assessment and only at the lowest effective dose without additional administration of thyroid hormones. If carbimazole is used during pregnancy, close maternal, foetal and neonatal monitoring is recommended (see section 4.4).

What is drug of choice for hyperthyroidism in pregnancy?

Results: Antithyroid drugs are the main therapy for maternal hyperthyroidism. Both methimazole (MMI) and propylthiouracil (PTU) may be used during pregnancy; however, PTU is preferred in the first trimester and should be replaced by MMI after this trimester.

Does Carbimazole cross the placenta?

Carbimazole crosses the placental barrier and can cause foetal harm.

What is the difference between propylthiouracil and methimazole?

Methimazole — Methimazole is usually preferred over propylthiouracil because it reverses hyperthyroidism more quickly and has fewer side effects. Methimazole requires an average of six weeks to lower T4 levels to normal and is often given before radioactive iodine treatment.

Why propylthiouracil is used in the 1st trimester of pregnancy but patients are then switched to methimazole in the 2nd 3rd trimester?

Because of the increased risk of birth defects with MMI as compared to PTU, the American Thyroid Association and the Endocrine Society guidelines recommend to use PTU to treat hyperthyroidism in the first trimester of pregnancy and then switch to MMI for the rest of the pregnancy.

How is hyperthyroidism treated during pregnancy?

In the first trimester of pregnancy, the preferred drug to treat hyperthyroidism is propylthiouracil (PTU). Another antithyroid drug, methimazole, may cause birth defects if taken during early in pregnancy. Women may need to take methimazole in the first three months of pregnancy if they cannot tolerate PTU.

What are the risks of taking propylthiouracil during pregnancy?

-To ensure minimum risk to the fetus, close clinical monitoring is needed to ensure the lowest effective dose is used. Untreated or inadequately treated Graves’ disease during pregnancy has been shown to increase the risk of maternal heart failure, spontaneous abortion, preterm birth, stillbirth, and fetal or neonatal hyperthyroidism.

Who is most at risk for hyperthyroidism during pregnancy?

Additionally, women with active Graves’ disease during pregnancy are at higher risk of developing very severe hyperthyroidism known as thyroid storm. Graves’ disease often improves during the third trimester of pregnancy and may worsen during the post partum period.

Are there any medications for hyperthyroidism in pregnancy?

ANTI-THYROID DRUG THERAPY (ATD). Methimazole (Tapazole) or propylthiouracil (PTU) are the ATDs available in the United States for the treatment of hyperthyroidism (see Hyperthyroidism brochure ). Both of these drugs cross the placenta and can potentially impair the baby’s thyroid function and cause fetal goiter.

How often does thyrotoxicosis occur in a pregnant woman?

Maternal thyrotoxicosis occurs about once in every 500 pregnancies, and the diagnosis may be difficult because the increase in cardiac output, tachycardia, skin warmth and heat intolerance typical of pregnancy can mimic hyperthyroidism.