What is the function of Globoside?
Globosides and gangliosides (the most complex) are complex glycosphingolipids that contain a ceramide and an oligosaccharide fragment. They are particularly abundant at nerve endings and at specific hormone receptor sites on cell surfaces and therefore play an important role in molecular recognition.
What are the differences between Cerebroside and ganglioside?
Cerebrosides contain a single sugar residue linked to ceramide, which is an N-acylsphingosine. Sulfatides contain a sulfate group attached to a sugar residue. Gangliosides (G) have oligosaccharide chains that contain sialic acid residues.
What does ganglioside mean?
A ganglioside is a molecule composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids (e.g. n-acetylneuraminic acid, NANA) linked on the sugar chain. Recently, gangliosides have been found to be highly important molecules in immunology.
What are the components of Galactocerebroside?
A galactosylceramide, or galactocerebroside is a type of cerebroside consisting of a ceramide with a galactose residue at the 1-hydroxyl moiety. The galactose is cleaved by galactosylceramidase. Galactosylceramide is a marker for oligodendrocytes in the brain, whether or not they form myelin.
Does Globoside contain sphingosine?
A glycosphingolipid is a glycolipid comprised of a carbohydrate and a sphingolipid — particularly one that has a sphingosine backbone. The carbohydrate is linked to a sphingolipid by a glycosidic bond.
Where are Cerebrosides found?
brain white matter
Cerebrosides are abundant in brain white matter and nerve myelin sheaths and they are present in small quantity within the cell membranes of other tissues. Brain white matter and, to a lesser extent, other tissues, also have lipids that contain sulfur.
Where are cerebrosides made?
Glucosylceramide (cerebroside) is derived from the degradation of glycosphingolipids, which are abundant in the plasma membranes of neurons and blood cells. Cerebroside is cleaved to glucose and free ceramide by the action of glucocerebrosidase.
What is Galactocerebroside made of?
What is a ganglioside made of?
Gangliosides are glycosphingolipids composed of a ceramide lipid tail attached through glycosidic linkage to a glycan headgroup containing one or more sialic acid residues (Figure 1).
What is galactocerebroside?
We show here that galactocerebroside (GC), the major glycolipid in myelin1, can serve as such a cell-surface marker for cultured rat oligodendrocytes, the glial cells responsible for making myelin in the central nervous system.