How do you dilute nitroglycerin?
Dilute in 5% Dextrose Injection or 0.9% Sodium Chloride Injection to a final concentration of 200 to 400 mcg/mL depending on patient’s fluid status. A common dilution is 50 mg in 250 mL of 5% Dextrose Injection or 0.9% Sodium Chloride Injection. The solution is stable for 48 hours at room temperature.
Can you inject nitroglycerin?
Nitroglycerin injection is used to treat hypertension (high blood pressure) during surgery or to control congestive heart failure in patients who have had a heart attack. It may also be used to produce hypotension (low blood pressure) during surgery.
What is Nitro used for?
Nitroglycerin sublingual tablets are used to treat episodes of angina (chest pain) in people who have coronary artery disease (narrowing of the blood vessels that supply blood to the heart). It is also used just before activities that may cause episodes of angina in order to prevent the angina from occurring.
What is GTN infusion used for?
An infusion of glyceryl trinitrate (GTN) is one of the key components in the treatment of acute left ventricular failure (LVF). Patients can be extremely unwell and are therefore often managed in the emergency department resuscitation room, a place where it is not unusual for larger intravenous cannulae to be sited.
How do you mix nitroglycerin?
Initial Dilution: Aseptically transfer the contents of one nitroglycerin vial (containing 25 mg or 50 mg of nitroglycerin) into a 500 mL glass bottle of either Dextrose (5%) Injection or Sodium Chloride Injection (0.9%). This yields a final concentration of 50 mcg/mL or 100 mcg/mL.
How do you administer nitroglycerin?
Adults—1 tablet placed under the tongue or between the cheek and gum at the first sign of an angina attack. 1 tablet may be used every 5 minutes as needed, for up to 15 minutes. Do not take more than 3 tablets in 15 minutes. To prevent angina from exercise or stress, use 1 tablet 5 to 10 minutes before the activity.
Does nitroglycerin increase heart rate?
More serious side effects include flushing of the head and neck can occur with nitroglycerin therapy as can an increase in heart rate or palpitations. This can be associated with a drop in blood pressure which can be accompanied by dizziness or weakness.
Why is glyceryl trinitrate given sublingually?
Antihypertensive Drugs and Vasodilators Glyceryl trinitrate (or nitroglycerin) undergoes extensive hepatic presystemic metabolism when given orally. Therefore, it is usually given by the sublingual route, by which it is well absorbed and rapidly taken up into the circulation.
What are the indications of nitroglycerin?
Nitroglycerin is indicated for various purposes. It is indicated to prevent and treat angina or chest pain due to cardiovascular disease, as well as to treat peri-operative hypertension or induce intra-operative hypotension. It is also indicated to treat acute heart failure in patients with myocardial infarction.